A client taking prednisone for several months says they plan to stop the medication because their symptoms are gone. What is the nurse's best response?

1. 1"You can stop it as long as you rinse your mouth well afterward."
2. 2"Stopping it is safe if you take an antihistamine instead of the drug."
3. 3"The medication is only needed when you have a bad flare of the disease."
4. 4"Stopping suddenly after long-term use can cause life-threatening adrenal insufficiency."

Source: Nursing Pharmacology, 2nd edition (Open RN, Chippewa Valley Technical College, 2023), Respiratory System: CORTICOSTERIODS. Licensed under CC BY 4.0.