Pharmacological and Parenteral TherapiesQuestion 2217 of 2368
A client who has taken the same medication for many months says it is less effective than before. Which process most likely explains this?
- The liver stopped producing the enzymes that metabolize the drug over time
- The drug is binding to inactive sites in fat tissue and is stored there
- The drug is no longer bound to plasma proteins in the bloodstream at all
- Repeated use induced liver enzymes that break down the drug, causing tolerance
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Correct answer: Repeated use induced liver enzymes that break down the drug, causing tolerance
Repeated use of a drug can induce more of the enzyme that metabolizes it. This causes tolerance and requires higher doses for the same effect.
Source: Nursing Pharmacology, 2nd edition (Open RN, Chippewa Valley Technical College, 2023), Pharmacokinetics & Pharmacodynamics: Factors Affecting Metabolism. Licensed under CC BY 4.0.
Practice the topic "Pharmacological and Parenteral Therapies"Questions last reviewed: 18 October 2026