Pharmacological and Parenteral TherapiesQuestion 1722 of 2368
Which age-related changes in distribution explain why many older adults require lower medication dosages?
- Less body fat and higher serum albumin, leaving less free drug in circulation
- More body fat and lower serum albumin, leaving more free drug in circulation
- More body fat and higher serum albumin, leaving less free drug in circulation
- Less body fat and greater first-pass metabolism, leaving less drug in circulation
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Correct answer: More body fat and lower serum albumin, leaving more free drug in circulation
Older adults have more body fat, which prolongs action of some drugs. Lower albumin leaves more active free drug in the body.
Source: Nursing Pharmacology, 2nd edition (Open RN, Chippewa Valley Technical College, 2023), Pharmacokinetics & Pharmacodynamics: OLDER ADULT. Licensed under CC BY 4.0.
Practice the topic "Pharmacological and Parenteral Therapies"Questions last reviewed: 18 October 2026