RN Exam Practice
Pharmacological and Parenteral TherapiesQuestion 1347 of 2368

A menopausal client who has a uterus is prescribed hormone replacement therapy. Why does it include both estrogen and progesterone?

  1. Estrogen alone can cause endometrial hyperplasia, which raises uterine cancer risk
  2. Progesterone prevents the blood clots that estrogen causes in the leg veins
  3. Estrogen alone has no effect on hot flashes or other menopausal symptoms
  4. Progesterone prevents the bone loss that estrogen causes in older clients
Show answer

Correct answer: Estrogen alone can cause endometrial hyperplasia, which raises uterine cancer risk

Progesterone opposes estrogen and prevents uncontrolled growth of the endometrial lining in clients with an intact uterus.

Source: Nursing Health Promotion (Open RN, Chippewa Valley Technical College, 2025), Reproductive System Alterations: Perimenopause and Menopause. Licensed under CC BY 4.0.

Practice the topic "Pharmacological and Parenteral Therapies"

Questions last reviewed: 18 October 2026