A client who takes an antidepressant tells the nurse about using St. John's wort. What is the nurse's best response?

1. 1"It is FDA approved for depression, so it is safe to take with your antidepressant."
2. 2"It will make your antidepressant work faster, so please take it every single day."
3. 3"Natural products never interact with prescribed medications, so it is fine to use."
4. 4"Please check with your provider first, since supplements can interact with medications."

Source: Nursing Health Promotion (Open RN, Chippewa Valley Technical College, 2025), Mental Health Conditions: Treatments for Depression. Licensed under CC BY 4.0.